Table 2 Univariate and multivariate Cox regression analyses DHRS4-AS1 for OS of patients in study cohort (n = 68)

Univariate analysis

 Age(≥ 60<60 vs. <60)

0.943

0.379–2.350

0.900

 Sex(female vs. male)

0.867

0.393–1.912

0.724

 Tumor size(≥ 5 cm vs<5 cm )

1.804

0.827–3.922

0.138

 Histologic differentiation(poorly + undifferentiated vs. well + moderately)

3.273

1.127–9.507

0.029^*

 Depth of invasion(T₃ + T₄ vs. T₁ + T₂)

6.667

0.902–49.273

0.063

 Lymphatic metastasis(yes vs. no)

3.028

1.213–7.554

0.018^*

 Metastasis(M₁ vs. M₀)

3.674

1.458–9.254

0.006

 TNM stage(III + IV vs. I + II)

4.127

1.553–10.969

0.004^*

 Nerve invasion(yes vs. no)

2.844

1.264−6.400

0.012^*

 Vascular invasion(yes vs. no)

2.403

1.109–5.206

0.026^*

 Expression of DHRS4-AS1 (high vs. low)

0.405

0.180–0.909

0.028^*

Multivariate analysis

 Lymphatic metastasis(yes vs. no)

1.380

0.286–6.670

0.688

 Histologic differentiation(poorly + undifferentiatedvs well + moderately)

1.787

0.567–5.635

0.322

 TNM stage(III + IV vs. I + II)

1.959

0.333–11.540

0.046^*

 Vascular invasion(yes vs. no)

0.629

0.259–1.528

0.306

 Expression of DHRS4-AS1 (low vs. high)

1.520

0.627–3.683

0.354