Fig. 5

Detection of hub predictive genes for developing the risk signature. A Volcano plot of DEGs between cancerous and healthy tissues in TCGA cohort; B volcano plot of prognosis-linked genes determined using the univariate Cox regression analysis; C trajectory of each independent variable with lambda, and plots of the coefficient distributions generated for the logarithmic (lambda) series used for parameter selection (lambda); D multivariate Cox coefficients for every risk signature gene. E, G K–M curves of the developed risk model based on the ten genes in the TCGA and GEO cohorts. F, H ROC curves of the developed risk model based on the ten genes in the TCGA and GEO cohorts