Fig. 7

Expression of NK cell-related receptors in WT and CAR-TIM3 NK-like cells upon co-incubation with leukemia cells. A–C Surface CD158 (A), CD161 (B), and Nkp30 (C) in WT and CAR-TIM3 NK-like cells in response to K562, KG-1, and TIM3-overexpressed U937 cells at various E:T ratios were evaluated by flow cytometric analysis, and their percentages were plotted. Data are mean ± SEM (n = 3). *p < 0.05; **p < 0.01; ***p < 0.001 and ****p < 0.0001 versus WT NK-like cells under the same conditions; unpaired t-test