Table 3 PRKCI genotype analysis according to metastasis and PCa stage
From: Possible prognostic impact of PKCι genetic variants in prostate cancer
Metastatic analysis | Analysis according to cancer stage | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotype | Metastatic (n = 44) | Non-Metastatic (n = 56) | Odds Ratio | 95% CI Odds Ratio | Relative Risk | 95% CI Relative risk | P value | Stage 1–2 (n = 39) | Stage 3–4 (n = 61) | Odds Ratio | 95% CI Odds Ratio | Relative Risk | 95% CI Relative risk | P value | |
n. (%) | n.(%) | n. (%) | n.(%) | ||||||||||||
GG | PRKCI rs1199520604 G34W | 10 (22.73%) | 28 (50%) | 0.2941 | 0.1186 to 0.6815 | 0.4799 | 0.2630 to 0.8185 | 0.0069 | 14 (35.90%) | 21 (34.42%) | 1.067 | 0.4482 to 2.415 | 1.040 | 0.6125 to 1.693 | > 0.9999 |
GT | 30(68.18%) | 24 (42.86%) | 2.578 | 1.117 to 5.905 | 1.714 | 1.078 to 2.828 | 0.0271 | 22 (56.41%) | 34 (55.74%) | 1.028 | 0.4724 to 2.252 | 1.017 | 0.6254 to 1.682 | > 0.9999 | |
TT | 4 (9.09%) | 4 (7.14%) | 1.300 | 0.3595 to 4.677 | 1.150 | 0.4823 to 1.973 | 0.7281 | 3 (7.69%) | 6 (9.84%) | 0.7639 | 0.1998 to 2.859 | 0.8426 | 0.2972 to 1.757 | > 0.9999 | |
G | 25 (52.17%) | 40 (55.56%) | 0.8727 | 0.4247 to 1.797 | 0.9205 | 0.5878 to 1.450 | 0.8499 | 25 (64.10%) | 38 (62.30%) | 1.081 | 0.4855 to 2.547 | 1.049 | 0.6414 to 1.785 | > 0.9999 | |
T | 19 (47.83) | 16 (44.44%) | 1.900 | 0.8517 to 4.391 | 1.411 | 0.9019 to 2.158 | 0.1443 | 14 (35.90%) | 23 (37.70%) | 0.9252 | 0.3926 to 2.060 | 0.9535 | 0.5603 to 1.559 | > 0.9999 | |
TT | PRKCI rs1197750201 (F66Y) | 34 (77.27%) | 29 (51.79%) | 3.166 | 1.364 to 7.847 | 1.997 | 1.173 to 3.641 | 0.0121 | 18 (46.15%) | 25 (40.98%) | 1.234 | 0.5674 to 2.671 | 1.136 | 0.6917 to 1.843 | 0.6807 |
AT | 4 (9.09%) | 6 (10.71%) | 0.8333 | 0.2520 to 3.011 | 0.9000 | 0.3691 to 1.663 | > 0.9999 | 2 (5.13%) | 8 (13.12%) | 0.3581 | 0.07379 to 1.639 | 0.4865 | 0.1354 to 1.304 | 0.3080 | |
AA | 6 (13.64%) | 21 (37.50%) | 0.2632 | 0.09588 to 0.7488 | 0.4269 | 0.1983 to 0.8233 | 0.0118 | 19 (48.72%) | 28 (45.90%) | 1.120 | 0.5216 to 2.401 | 1.071 | 0.6546 to 1.745 | 0.8388 | |
A | 36 (81.82%) | 24 (42.86%) | 0.2250 | 0.07353 to 0.8497 | 3.000 | 1.646 to 5.875 | < 0.0001 | 19 (48.72%) | 32 (52.46%) | 0.8609 | 0.4003 to 1.877 | 0.9127 | 0.5582 to 1.489 | 0.8378 | |
T | 8 (18.18%) | 32 (57.14%) | 0.06622 to 0.4137 | 0.1180 to 0.7432 | 0.3333 | 0.1702 to 0.6075 | 0.00100 | 20 (51.28%) | 29 (47.54%) | 1.162 | 0.5328 to 2.498 | 1.096 | 0.6714 to 1.792 | 0.8378 | |