Fig. 2

Identification of disulfidptosis-regulated clusters based on 16 DRGs in HCC. A Differences in the expression levels of 16 DRGs in HCC and normal tissue, most of those genes were significantly upregulated in HCC tissues. (B) CNV (amplification and deletion) frequencies of DRGs in HCC. (C) The location of CNVs of DRGs on 23 chromosomes. (D) Boxplot showing the significant difference in the immune score between the two disulfidptosis-regulated clusters in the TCGA cohort (Wilcoxon test, * P < 0.05). (E and F) The prognosis analysis for two disulfidptosis-regulated clusters: Cluster 1 had lower overall survival (OS) and progression-free interval (PFI) than Cluster 2. P values are shown as * P < 0.05; ** P < 0.01; *** P < 0.001; ns, not significant. DRGs Disulfidptosis-related genes, HCC hepatocellular carcinoma, CNV copy number variation, OS overall survival, PFI progression-free interval, TIME tumor immune microenvironment