Fig. 5

Evaluation of tumor microenvironment (TME) features based on the DRG score. A Boxplot showing that the immune score of the high-DRG group was significantly higher than that of the low-DRG score group in the TCGA cohort (Wilcoxon test, *** P < 0.001). B CIBERSORT analysis of correlations between the proportion of immune cells and 19 hub genes showed that these genes in HCC patients in the TCGA cohort were closely related to macrophages, B cells, NK cells and T cells. C Boxplot showing the proportion of immune cells in the low- and high-DRG score groups in HCC patients, which suggested that the high DRG score group had higher infiltration levels of macrophages and Tregs and lower infiltration levels of naive B cells, CD4 + T cells and CD8 + T cells. D–J The immune checkpoint genes (CD274, PDCD1, CTLA4, CD276, HAVCR2, TIGIT and IDO1) significantly correlated with the DRG score. P values are shown as * P < 0.05; ** P < 0.01; *** P < 0.001; ns, not significant. HCC hepatocellular carcinoma, TME tumor microenvironment, DRGs Disulfidptosis-related genes