Fig. 2From: AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathwayThe binding of AAA237 to Skp2 inhibited Skp2 substrate degradation. Cellular thermal shift assay of Skp2 with AAA237 in U251 (A, B) and LN229 (C, D). Western blot analysis for protein levels of Skp2, p21Cip1 and p27Kip1 in U251 (E) and LN229 (F) cells after treatment of AAA237Back to article page