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Fig. 3 | Cancer Cell International

Fig. 3

From: AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway

Fig. 3

AAA237 dose-dependently inhibited colony formation, migration, and invasion of GBM cells. EdU-DNA synthesis assay shows that AAA237 inhibits DNA synthesis at 48 h in U251 (A) and LN229 (B) cells. Meanwhile, AAA237 inhibits DNA synthesis at 72 h in U251 (C) and LN229 (D) cells. Scale bar = 100 μm. E Matrigel assay showed that AAA237 reduced the colony formation of U251 and LN229 cells. F Soft agar assay showed that AAA237 reduced the colony formation of U251 and LN229 cells. The experiments were performed in triplicate, and scale bar = 100 μm. Transwell assay showed that AAA237 inhibited the migration and invasion of U251 (G–H) and LN229 (I–J) cells

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Cancer Cell International

ISSN: 1475-2867

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