Non-coding RNAs as potential therapeutic targets for receptor tyrosine kinase signaling in solid tumors: current status and future directions

Moeinafshar, Aysan; Nouri, Mohammad; Shokrollahi, Nima; Masrour, Mahdi; Behnam, Amirmohammad; Tehrani Fateh, Sahand; Sadeghi, Hossein; Miryounesi, Mohammad; Ghasemi, Mohammad-Reza

doi:10.1186/s12935-023-03203-2

Table 1 Summary of the studies conducted on application of commonly investigated miRNAs as biomarkers in solid tumors

From: Non-coding RNAs as potential therapeutic targets for receptor tyrosine kinase signaling in solid tumors: current status and future directions

Malignancy	MicroRNA	Target	N. of cases	Pattern of alteration	Application	Site of measurement	Validity	Associated determinants of prognosis	References
Breast cancer	miR-21	PTEN	102	Up-regulation	Diagnostic, prognostic	Serum	AUC = 0.721	Visceral metastasis (p < 0.001)	[209]
	miR-195	Raf1	210	Down-regulation	Diagnostic, treatment response	Serum	AUC = 0.859	–	[210, 211]
	miR-155	SOCS1	103	Up-regulation	Diagnostic, treatment response	Serum	AUC = 0.801	–	[95, 212]
Colorectal cancer	miR-21	PTEN	200	Up-regulation	Diagnostic	Serum	AUC = 0.802	–	[213]
	miR-92a	PTEN	200	Up-regulation	Diagnostic, prognostic	Serum	AUC = 0.786	Poor survival (p = 0.03)	[213, 214]
	miR-200c	ZEB1/ZEB2	446	Up-regulation	Prognostic	Serum	–	Higher disease stage, lymph node metastasis (p = 0.0026), distant metastasis (0.0023), overall survival (p = 0.0064), tumor recurrence (HR = 4.51, p = 0.005)	[102, 215]
Gastric cancer	miR-182	FOXO1	47	Down-regulation	Diagnostic	Serum	AUC = 0.898	–	[216, 217]
	miR-21	PTEN	50	Up-regulation	Diagnostic	Serum, PBMC	AUC = 0.912 (serum), AUC = 0.898 (PBMC)	–	[218]
	miR-106b	ALEX1	90	Up-regulation	Diagnostic	Plasma	AUC = 0.7733	–	[219, 220]
Pancreatic cancer	miR-21	PTEN	49	Up-regulation	Diagnostic	Plasma	AUC = 0.62	–	[221, 222]
	miR-7	MAP3K1	8	Down-regulation	Prognostic	Plasma	–	Advanced tumor stage, poor survival	[223, 224]
	200c	ZEB1/ZEB2	84	Up-regulation	Prognostic	Tissue	–	Poor overall survival (p = 0.013)	[102, 225]
HCC	miR-122	IGF1R	50	Up-regulation	Diagnostic, prognostic	Serum	AUC = 0.954	Favorite prognosis (p < 0.001)	[226, 227]
HCC	miR-21	PTEN	126	Up-regulation	Diagnostic	Plasma	AUC = 0.953	–	[221, 228]
NSCLC	miR-21	PTEN	152	Up-regulation	Diagnostic, prognostic	Serum	AUC = 0.81	Tumor size (p = 0.001), higher TNM stage (p = 0.004)	[221, 229]
	miR-126	VEGF	112	Up-regulation	Diagnostic	Serum	AUC = 0.793	–	[230, 231]
	let7c	IGF1R	120	Down-regulation	Diagnostic	Plasma	AUC = 0.714	–	[232, 233]

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