Table 4 Summary of the studies conducted on the therapeutic application of lncRNAs in solid tumors
ncRNA | Target | Malignancy | Type of study | Results | References |
|---|---|---|---|---|---|
TMPO-AS1 | ERBB2 | NSCLC | In vitro | LncRNA TMPO-AS1 facilitates the proliferation and metastasis of NSCLC cells by up-regulating ERBB2 via sponging miR-204-3p | [160] |
DANCR | ERBB2 | NSCLC | In vitro | LncRNA DANCR promoted non-small cell lung cancer cells metastasis via modulating of miR-1225-3p/ErbB2 signal | [234] |
MIR137HG | MET | Gastric cancer | In vitro | MiR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer | [235] |
CALIC | AXL | Colon cancer | In vivo | The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis | [167] |
XIST | AXL | Colon cancer | In vivo/in vitro | LncRNA XIST modulates HIF‐1A/AXL signaling pathway by inhibiting miR‐93‐5p in colorectal cancer | [162] |
XIST | ROR1 | Colon cancer | Clinical trial | Atractylenolide II reverses the influence of lncRNA XIST/miR‐30a‐5p/ROR1 axis on chemo‐resistance of colorectal cancer cells | [163] |
MALAT1 | AXL | Neuroblastoma | In vitro | LncRNA-MALAT1-mediated Axl promotes cell invasion and migration in human neuroblastoma | [166] |
TINCR | AXL | Melanoma | In vivo/in vitro | LncRNA TINCR attenuates the proliferation and invasion, and enhances the apoptosis of cutaneous malignant melanoma cells by regulating the miR-424-5p/LATS1 axis | [236] |
GAS6-AS2 | AXL | Melanoma | In vivo/in vitro | Increased expression of long noncoding RNA GAS6-AS2 promotes proliferation and inhibits apoptosis of melanoma cells via upregulating GAS6 expression | [237] |
LINC00852 | AXL | Osteosarcoma | In vivo/in vitro | Exosome-transmitted linc00852 associated with receptor tyrosine kinase AXL dysregulates the proliferation and invasion of osteosarcoma | [159] |
HULC | MET | HCC | In vivo/in vitro | The lncRNA “highly upregulated in liver cancer” (HULC) promotes MET expression through sponging miR-2052 in HCC | [161] |
TUSC | Eph | HCC | In vitro | LncRNA TUSC7 acts a molecular sponge for miR-10a and suppresses EMT in hepatocellular carcinoma | [174] |
LINC00526 | AXL | Glioma | In vitro | LncRNA LINC00526 represses glioma progression via forming a double negative feedback loop with AXL | [171] |
LIMT | EGF | Breast cancer | In vivo/in vitro | LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer | [172] |
H19 | EGFR and c-met | Breast cancer | In vitro | H19 ncRNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b | [165] |
MAYA | HER3, ROR1 | Breast cancer | In vivo/in vitro | The orphan receptor tyrosine kinase ROR1 can form heterodimers with other RTKs, such as HER3, to activate signaling pathways that promote cancer cell proliferation, survival, and invasion | [169] |
MALAT1 | RTKs | Thyroid cancer | In vitro | Transcript-level regulation of MALAT1-mediated cell cycle and apoptosis genes using dual MEK/Aurora kinase inhibitor “BI-847325” on anaplastic thyroid carcinoma | [168] |
HOTAIR | AXL | RCC | In vivo/in vitro | LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma | [158] |