Table 6 Summary of the studies conducted on the therapeutic application of circRNAs in solid tumors

Hsa_circ_0070661

TEK + BB3:B23

Lung adenocarcinoma

In vivo/in vitro

Hsa_circ_0070661 inhibits cancer progression through miR-556-5p/TEK axis in lung adenocarcinoma

[187]

Circ_0001058

TEK

Lung adenocarcinoma

In vivo/in vitro

Circ_0001058 represses the progression of lung adenocarcinoma through governing of the miR-486-5p/TEK signaling axis

[188]

circ7312

EGFR-TKI

Lung adenocarcinoma

In vivo/Invitro

Hsa_circ_0007312 Promotes Third-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance through Pyroptosis and Apoptosis via the MiR-764/MAPK1 Axis in Lung Adenocarcinoma Cells. J Cancer

[201]

circ-0003748

EGFR-TKI

Lung adenocarcinoma

In vitro

Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance

[238]

circ-0001398

EGFR-TKI

Lung adenocarcinoma

In vitro

Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance

[238]

hsa_circ_0005576

IGF1R

Lung adenocarcinoma

In vivo/in vitro

Hsa_circ_0005576 promotes osimertinib resistance through the miR-512-5p/IGF1R axis in lung adenocarcinoma cells

[203]

hsa_circ_0012673

ERBB3

Lung adenocarcinoma

In vitro

Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation

[189]

Circ_0014235

EGFR-TKI

NSCLC

In vivo/in vitro

Circ_0014235 confers Gefitinib resistance and malignant behaviors in non-small cell lung cancer resistant to Gefitinib by governing the miR-146b-5p/YAP/PD-L1 pathway

[202]

circRNA_102481

ROR1

NSCLC

In vitro

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer

[196]

hsa_circ_0109320

EGFR-TKI

NSCLC

Clinical Trial

Circular RNA profiling identified as a biomarker for predicting the efficacy of Gefitinib therapy for non-small cell lung cancer

[205]

circ-ERBB2

ERBB2

Lung cancer

In vivo/in vitro

Propofol suppresses lung cancer tumorigenesis by modulating the circ-ERBB2/miR-7-5p/FOXM1 axis

[204]

circFAM53B

c-met

Glioma

In vivo/in vitro

CircFAM53B promotes the proliferation and metastasis of glioma through activating the c-MET/PI3K/AKT pathway via sponging miR-532-3p

[190]

Circ_0001588

EPHB4

Glioma

In vivo/in vitro

. Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281

[191]

circ_0001162

EPHB4

Glioma

In vivo/in vitro

circ_0001162 promotes cell proliferation and invasion of glioma via the miR-936/ERBB4 axis

[192]

hsa_circ_0081519

EPHB4

Glioma

In vivo

. CircRNA EPHB4 modulates stem properties and proliferation of gliomas via sponging miR-637 and up-regulating SOX10

[193]

Circ_0044520

ROR2

Laryngeal squamous cell carcinoma

In vivo

. Circ_0044520 regulates the progression of laryngeal squamous cell carcinoma via the miR-338-3p/ROR2 axis

[194]

circ_0000745

ERBB4

Ovarian cancer

In vivo

. RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells

[199]

hsa_circ_0006470

ROR1

Gastric cancer

In vitro

circRNA_0006470 promotes the proliferation and migration of gastric cancer cells by functioning as a sponge of miR-27b-3p

[195]

circ_0079558

MET

PTC

In vivo

Circ_0079558 promotes papillary thyroid cancer progression by binding to miR-26b-5p to activate MET/AKT signaling

[198]

circ-NSD2

DDR1

Colorectal cancer

In vivo/in vitro

NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signaling

[197]

circ-LAMP1

DDR2

T-cell Lymphoblastic Lymphoma

In vitro

Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression

[200]