Fig. 4

Quantitative assessment of Coilin as a Cajal body marker in platinum drug responses in prostate cancer cells. A Numbers of CBs in nuclei of the indicated cell lines treated by the indicated drugs as measured with Coilin dots. B Size of CBs of the indicated cell lines treated by the indicated drugs as measured with Coilin spot diameter. C Western blot analysis of Coilin protein levels in the indicated cell lines treated by platinum drugs. Left panel, representative blot images. Tubulin and lamin shown as loading controls, non-specific bands indicated with an asterisk. Right panel, relative signal intensity for three replicate experiments for each cell line. Mean values with S.D., *p-value < 0.05, **p-value < 0.01