Fig. 1

Association between Cuproptosis and Ferroptosis. Glutathione (GSH) inhibits cuproptosis; on the other hand, it can inhibit ferroptosis by inhibiting ROS. High levels of copper induce activation of the tumor suppressor gene p53, the activity of which may promote cuproptosis by enhancing mitochondrial function; p53 can inhibit the expression of the SLC7A11 gene, affect the balance of ROS and GSH, reduce cell uptake of cystine, and reduce cell antioxidant capacity, thereby promoting ferroptosis in tumor cells. Moreover, coenzyme Q10 (CoQ10) on the mitochondria is reduced to reduced coenzyme Q10 (CoQ10H2), which may inhibit ROS and lead to ferroptosis inhibition