Fig. 3
UPRmt was activated and mitochondrial function was enhanced in A2780 cells. A A2780 and SKOV3 cells were treated with PKI-402 (2.5 μM) for 12 h, mitochondrial proteins were collected and mitochondrial protease expression and molecular chaperone expression were analyzed by Western blotting. B The expression of the proteins in A were measured by Western blotting, respectively. Data were expressed as mean ± SEM of three independent experiments; *P < 0.05, **P < 0.01 compared to the control. D A2780 and SKOV3 cells were treated with PKI-402 (2.5 μM) for 12 h and then incubated with JC-1. The changes in fluorescence intensity were measured by flow cytometry. E A2780 and SKOV3 cells were treated with PKI-402 (2.5 μM) for 12 h and then incubated with DCFH-DA. The changes in fluorescence intensity were measured by flow cytometry