Fig. 4
From: Melanoma biology and treatment: a review of novel regulated cell death-based approaches
The relationship between ferroptosis and melanoma. Ferroptosis is characterized by the overwhelming production of ROS and accumulation of iron-dependent lipid peroxides. Research of ferroptosis on melnoma was expressed in white squares with reference number in parenthesis. The exogenous molecules are marked in blue squares especially. Ferroptosis can be induced in melanoma cells by GPX4 inhibition in the situation of BRAF inhibitor resistance or with the application of plant-derived phyto-sesquiterpene lactone. Nobiletin can also induce ferroptosis in melanoma cells through another pathway of GSK3β-mediated Keap1/Nrf2/HO-1 signaling. In addition, IFNγ release after immunotherapy can drive ferroptosis by downregulating the expression of system Xc−. which can be further enhanced by the delivery of miR-21-3p-loaded gold nanoparticles