Fig. 5

Screening of therapeutic reagents using MNOs. A Cytotoxicity was evaluated by LDH assays after treatment with four drugs for 72 h. Kruskal–Wallis test was performed with Dunn's post hoc correction (n = 6; *P < 0.05, **P < 0.01; ***P < 0.001). B 3D invasion assays after treatment with four drugs. Representative images were captured in MNO21-03 (Scale bar, 500 µm) and invasiveness was quantified at 7 d using ToupView software. One-way ANOVA was performed after confirmation of normality using Shapiro–Wilk test (*P < 0.05, **P < 0.01)