Fig. 10

Analysis of drug sensitivity and cytotoxicity in gastric cancer cells. A The scatter plot illustrates the cross-association scores of predictivity and descriptivity that were used to identify potent drugs with efficacy against STAD cells. To identify gene signatures and potential drugs, we queried the pharmacogenetics database for the ALKBH1 gene. We then evaluated the drug sensitivity of the sgALKBH1 gene to various chemical drugs in STAD cell lines. The boxplots B–G depict the log of the half maximal inhibitory concentration (IC50) values for six drugs, namely Elesclomol, Vinorelbine, Alisertib, ZM447439, RU-SKI 43, and FTY-720, that showed altered potency