Fig. 6
From: Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib
The ESPL1 and MDM2 mRNA level was up-regulated in apatinib resistant GC cells. a ESPL1 mRNA level in AGS and HGC27 cells was detected, the apatinib-resistant cells of GC cells were enriched by treating with 10 μg/mL apatinib for two weeks; b UbiBrowser was used to predict ubiquitin ligase of ESPL1. c Correlation analysis of ESPL1 and MDM2 by the mRNA data in TCGA; d MDM2 mRNA level in AGS and HGC27 cells was detected, the apatinib-resistant cells of GC cells were enriched by treating with 10 μg/mL apatinib for two weeks. Statistical significance was determined by One-way ANOVA and Pearson correlation analysis. Data were represented as means ± SD. ***P < 0.001 compared with the NC group