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Fig. 3 | Cancer Cell International

Fig. 3

From: The anti-tumor effects of AZD4547 on ovarian cancer cells: differential responses based on c-Met and FGF19/FGFR4 expression

Fig. 3

AZD4547 inhibited tumor growth in ovarian cancer- and EOC patient–derived xenograft models. (A) A2780-, (B) SKOV3ip1-, (C) A2780-CP20-, and (D) SKOV3-TR-derived xenograft and (E) EOC PDX mice. Groups treated with AZD4547 (n = 10) exhibited significantly decreased tumor weight compared with the control group (n = 10). Top panels show tumor weights and bottom panels show tumor cell proliferation based on Ki-67 immunohistochemistry of harvested tumor tissues (n = 5 for each group) and TUNEL assays (*p < 0.05). In (E), images of tumors obtained from PDX mice are compared with kidney tissue obtained from the same mouse

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Cancer Cell International

ISSN: 1475-2867

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