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Fig. 4 | Cancer Cell International

Fig. 4

From: The anti-tumor effects of AZD4547 on ovarian cancer cells: differential responses based on c-Met and FGF19/FGFR4 expression

Fig. 4

Inhibition of FGFR1 activation and downstream signaling by AZD4547 were dependent on the EOC cell lines and chemo-sensitive PDX. AZD4547 was applied for different durations in EOC cells. Phospho-FGFR1 and phosphorylation of downstream signaling proteins including p-AKT and p-ERK were investigated in cell lysates and tumor lysates obtained from AZD4547-treated PDX mice compared with control-treated mice by western blot analysis. β-actin was used as a loading control

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Cancer Cell International

ISSN: 1475-2867

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