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Fig. 1 | Cancer Cell International

Fig. 1

From: The m6A methyltransferase METTL3 drives thyroid cancer progression and lymph node metastasis by targeting LINC00894

Fig. 1

Decreased Expression of LINC00894 in PTC Tissues and Cells. (A) Relative LINC00894 expression in normal thyroid tissue, PTC tissue without lymphatic metastasis, and PTC tissue with lymphatic metastasis using GEO (GSE60542). (B) Venn diagram showing the overlapping differentially expressed lncRNAs, depending on A1 and A2. (C) Assessment of LINC00894 expression in normal thyroid tissue, PTC tissue without lymphatic metastasis, and PTC tissue with lymphatic metastasis (PTC-LNM) using TCGA data. (D) Assessment of LINC00894 expression in normal thyroid tissue using the Genotype-Tissue Expression (GTEx) database. (E) Assessment of LINC00894 expression in normal and tumour tissues using the Gene Expression Profiling Interactive Analysis (GEPIA) database. (F) Assessment of LINC00894 expression in THCA based on TCGA data. (G) Assessment of LINC00894 expression in THCA using GEPIA data. (H) QRT-PCR analysis of LINC00894 expression levels in PTC cell lines. (I) Analysis of the clinical impacts of abnormal LINC00894 expression on PTC patient overall survival using Kaplan‒Meier Plotter. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Cancer Cell International

ISSN: 1475-2867

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