Skip to main content
Fig. 5 | Cancer Cell International

Fig. 5

From: Impact of NDUFAF6 on breast cancer prognosis: linking mitochondrial regulation to immune response and PD-L1 expression

Fig. 5

Differential expression of NDUFAF6 in breast cancer and enrichment of associated biological functions and pathways. A Volcano plot of DEGs between high and low NDUFAF6 expression groups, with red indicating upregulation and blue indicating downregulation. B Heatmap of the top 10 differentially expressed genes between high and low NDUFAF6 expression groups. C PPI network of NDUFAF6 and its co-expressed genes. D, E GO and KEGG enrichment analysis based on NDUFAF6 differentially expressed genes and visualization of immunity-related pathways. F–K Enrichment plots from GSEA include F Leishmania infection, G Parasite infection, H IL12 pathway, I NRF2 pathway, J allograft rejection, and K Viral myocarditis. L Western Blot validation of changes in NRF2 in MCF-7 cell xenografts after silencing or overexpressing NDUFAF6 (n = 5)

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us