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Fig. 6 | Cancer Cell International

Fig. 6

From: An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2

Fig. 6

LncRNA NCALD may interact directly with ERα. Cell immunofluorescence assay revealed the colocalization of lncRNA NCALD with ERα in MCF7 and T47D cells (panel a). RNA pull-down assay (b, c) and RIP (d) assay indicated a significant interaction between ERα and ncRNA NCALD (n = 3, ***P < 0.001) (panels b–d). The results of the RNA pull-down (e) and RIP (f) assays demonstrated that the fragment spanning nucleotides 1-121 of ERα interacted with lncRNA NCALD at position 1-151 (n = 3, **P < 0.01) (panels e–f)

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Cancer Cell International

ISSN: 1475-2867

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