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Fig. 2 | Cancer Cell International

Fig. 2

From: A cuproptosis-related gene expression signature predicting clinical prognosis and immune responses in intrahepatic cholangiocarcinoma detected by single-cell RNA sequence analysis

Fig. 2

Overview of scRNA data and gene screening. A t-SNE plot of cell clusters in ICC. B Bubble diagram displaying ICC marker genes in each gene cluster. C t-SNE plot of cell types in ICC. D Heatmap of differentially expressed genes in different cell types. E Analysis of cell–cell communication between various cell types. A cluster is represented by the nodes, while the number of interactions is indicated by the thickness of the lines between them. F A bubble diagram of each cuproptosis gene in ICC clusters. G A dynamic tree-pruning was used to combine genes with comparable cuproptosis-score patterns into a single module, resulting in a hierarchically clustered tree. H Correlation coefficients and matching p-values between CUPT score (CUPTS) and each gene module are shown in boxes

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Cancer Cell International

ISSN: 1475-2867

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