Fig. 1

Expression of IR-A and IR-B in different cancer types. A IR isoforms in GEPIA (Gene Expression Profiling Interactive Analysis). INSR-001: IR-B, INSR-002: IR-A. Furin-like: The furin-like structure domain is capable of cleaving specific peptide chains, thus participating in the processing and activation of certain proteins during the alternative splicing process. Pkinase_Tyr: The Pkinase_Tyr domain is capable of regulating the activation status of relevant signaling pathways during alternative splicing. Recep_L_domain: The Recep_L domain structure can mediate RNA-RNA or RNA–protein interactions during the process of alternative splicing, thereby influencing splice site selection and efficiency. B.C Violin plot (B) and box plot (C) showing the expression level of IR-A and IR-B in different cancer types by isoform usage profiling in GEPIA. INSR-001 IR-B, INSR-002 IR-A. ACC Adrenocortical carcinoma, BLCA Bladder Urothelial Carcinoma, BRCA Breast invasive carcinoma, CESC Cervical squamous cell carcinoma and endocervical adenocarcinoma, CHOL Cholangiocarcinoma, COAD Colon adenocarcinoma, DLBC Lymphoid Neoplasm Diffuse Large B-cell Lymphoma, ESCA Esophageal carcinoma, GBM Glioblastoma multiforme, HNSC Head and Neck squamous cell carcinoma, KICH Kidney Chromophobe, KIRC Kidney renal clear cell carcinoma, KIRP Kidney renal papillary cell carcinoma, LAML Acute Myeloid Leukemia, LGG Brain Lower Grade Glioma, LIHC Liver hepatocellular carcinoma, LUAD Lung adenocarcinoma, LUSC Lung squamous cell carcinoma, MESO Mesothelioma, OV Ovarian serous cystadenocarcinoma, PAAD Pancreatic adenocarcinoma, PCPG Pheochromocytoma and Paraganglioma, PRAD Prostate adenocarcinoma, READ Rectum adenocarcinoma, SARC Sarcoma, SKCM Skin Cutaneous Melanoma, STAD Stomach adenocarcinoma, TGCT Testicular Germ Cell Tumors, THCA Thyroid carcinoma, THYM Thymoma, UCEC Uterine Corpus Endometrial Carcinoma, UCS Uterine Carcinosarcoma, UVM Uveal Melanoma