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Fig. 4 | Cancer Cell International

Fig. 4

From: Extracellular vesicles produced by irradiated endothelial or Glioblastoma stem cells promote tumor growth and vascularization modulating tumor microenvironment

Fig. 4

Filamin-B and Periostin transcripts are enriched in EVs isolated after irradiation. A. GSEA of highly modulated genes as assessed by RNA-Seq on EVs derived from irradiated GSC#61 (50 Gy) compared to EVs derived from sham-irradiated GSC#61 (upper panel). qRT-PCR analysis of CENPJ, CNTROB, FLNB and LMNB expression in GSC-derived EVs isolated from sham irradiated (EVs) and irradiated (EVs 50 Gy) GSC#61 (lower panel). Samples were run in duplicate. Data were normalized to the GAPDH expression in the corresponding samples. B. GSEA of highly modulated genes as assessed by RNA-Seq on EVs derived from irradiated HMVECs (50 Gy) compared to EVs derived from sham-irradiated HMVECs (upper panel). qRT-PCR analysis of GEM, MCM7, PMEPA1 and POSTN expression in HMVEC-derived EVs isolated from sham irradiated (EVs) and irradiated cells (EVs 50 Gy). Samples were run in duplicate. Data were normalized to the GAPDH expression in the corresponding samples

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Cancer Cell International

ISSN: 1475-2867

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