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Fig. 1 | Cancer Cell International

Fig. 1

From: Novel lncRNAs LINC01221, RP11-472G21.2 and CRNDE are markers of differential expression in pediatric patients with T cell acute lymphoblastic leukemia

Fig. 1

Differential expression of mRNA and lncRNAs in pediatric T-ALL (N = 25). A, Cluster analysis of mRNA expression in T-ALL samples ( turquoise) and healthy controls (red). B, Pathways associated with upregulated and downregulated mRNA in T-ALL. C, Heatmap of Top 20 differentially expressed lncRNAs, upregulated and downregulated (p < 0.01, fold-change > 2.0). D, Volcano plot of upregulated and downregulated lncRNAs. The horizontal dashed line represents a threshold of adjusted p value (< 0.01). The vertical dashed line represents the thresholds of fold change (> 1.5). Red dots represent the statistically significant differentially expressed lncRNAs. Upregulated lncRNAs validated in discovery cohort are outlined in red colour. E, Bar plot representing total number of upregulated and downregulated lncRNAs and mRNAs in T-ALL.

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Cancer Cell International

ISSN: 1475-2867

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