Fig. 2

Construction the risk signature in training cohort. A Heatmap was drawn to show the DEGs between normal cervical tissues and CESC with the following criterion: |logFC|> 1 and adjust P value < 0.05; B A total of 398 DEGs were presented in volcano plot, up-regulated DEGs were displayed as red points and down-regulated DEGs were displayed as green points; C Top 10 enriched biological process of these 398 DEGs; D KEGG enrichment results of these 398 DEGs; E 26 DEGs showed statistical significance (P < 0.05) through univariate Cox regression, DEGs with HR < 1 were presented as blue bars and DEGs with HR > 1 were presented as red bars, the bars’ length represent the 95% confidence interval; F 16 DEGs were selected through lasso Cox regression by tenfold cross validation, red represent the risk DEGs and blue represent the protective DEGs; G 10 DEGs were finally gathered through step-wise multivariate Cox regression to construct the risk signature