Fig. 3

Overexpression of YY1 might suppress the infiltration of immune cells in GC. (A) YY1 expression was negatively correlated to IMMUNE (r = -0.220, p < 0.001), STROMAL (r = -0.095, p = 0.065), and ESTIMATE (r = -0.175, p < 0.001) scores. (B) CIBERSORT predicted that the expression of YY1 significantly suppressed immune cell infiltration. (C) The TIMER 2.0 showed that the infiltration of CD8 + T cells (Rho = -0.136, p < 0.001), B memory cells (Rho = -0.201, p < 0.001), active NK cells (Rho = -0.165, p < 0.001), and monocytes (Rho = -0.113, p < 0.001) was significantly reduced in tumor tissues, while the infiltration of NK resting cells (Rho = 0.15, p < 0.001) and macrophages (Rho = 0.262, p < 0.001) was enhanced