Fig. 1

Transcriptional variance and expression of CRGs, and experimental validation and functional enrichment of CRGs in NSCLC. (A) Frequency and location of the copy number variation (CNV); (B) Variance of the expression of 18 CRGs from TCGA database in the normal and tumor tissues; (C) Prognosis-related network of expression of18 CRGs from TCGA database; (D) Tumor mutation burden (TMB) of 18 CRGs from TCGA database; (E) PCR validation of the CRGs expression level of the tumor and normal tissues; (F, G) KEGG functional enrichment of CRGs; (H, I) GO functional enrichment of CRGs (*P < 0.05; ** P < 0.01; and *** P < 0.001; Ns, not significant). CRGs, cuproptosis-related genes; NSCLC, non-small-cell lung cancer; CNV, copy number variation; TMB, tumor mutation burden; KEGG, Kyoto Encyclopedia of Genes and Genomes; GO, gene ontology