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Fig. 5 | Cancer Cell International

Fig. 5

From: SLC25A17 inhibits autophagy to promote triple-negative breast cancer tumorigenesis by ROS-mediated JAK2/STAT3 signaling pathway

Fig. 5

SLC25A17 knockdown inhibited motility and proliferation mediated by autophagy. A, B Apoptosis analysis and colony formation in SLC25A17 knockdown MDA-MB-231 cells with or without 3-MA (5 mM). 3-MA: 3-methyladenine. C The protein levels of LC3-I, LC3-II, P62, cleaved caspase-3, cleaved-PARP, E-cadherin, Vimentin and MMP9 were detected by western blotting in MDA-MB-231 cells. D, E Representative transwell migration and invasion images and statistics for the number of migrated and invaded TNBC cells in SLC25A17 knockdown MDA-MB-231 cells with or without 3-MA (5 mM). * p < 0.05, ** p < 0.01, *** p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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