Fig. 7

SLC25A17 knockdown inhibited JAK2/STAT3 pathway in TNBC cells. A The protein levels of phosphorylated STAT3 (p-STAT3) and phosphorylated JAK2 (p-JAK2) was detected by western blot in MDA-MB-231 and MDA-MB-468 cells. B The protein levels of p-STAT3 and its downstream protein Cyclin D and Bcl-2 were detected by western blot in MDA-MB-231 and MDA-MB-468 cells treated with or without NAC (5 mM). C The protein levels of autophagy and apoptosis-related proteins was detected by western blot in MDA-MB-231 and MDA-MB-468 cells treated with or without IL-6 (50 ng/mL). D Colony formation in SLC25A17 knockdown MDA-MB-231 cells with or without IL-6 (50 ng/mL). E Representative transwell invasion images and statistics for the number of invaded cells in SLC25A17 knockdown MDA-MB-231 cells with or without IL-6 (50 ng/mL). * p < 0.05, ** p < 0.01, *** p < 0.001