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Fig. 8 | Cancer Cell International

Fig. 8

From: SLC25A17 inhibits autophagy to promote triple-negative breast cancer tumorigenesis by ROS-mediated JAK2/STAT3 signaling pathway

Fig. 8

Knockdown of SLC25A17 inhibited the growth and metastasis of xenograft tumors in vivo. A Gross appearance of tumors from BALB/c nude mice injected with MDA-MB-231 cells with or without SLC25A17 knockdown. B The subcutaneous tumor volumes were tracked for 24 days. C Quantification of subcutaneous tumor weight of the nude mice in each group. D Representative IHC staining of p-STAT3, LC3, Ki-67 and cleaved-caspase3 in tumor tissues. (scale bar: 100 μm). E The protein level of LC3, Bcl-2, P62, Cyclin D, cleaved caspase 3 and p-STAT3 by western blot in xenograft tumors. F Proposed possible mechanism of SLC25A17 functions in TNBC. SLC25A17 inhibits apoptosis and autophagy by the regulation of ROS/JAK2/STAT3 signaling pathways. Image created using biorender.com. * p < 0.05, ** p < 0.01, *** p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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