Table 1 Comparison of preclinical models commonly used in CAR-T therapy reaserch
From: Application status and optimization suggestions of tumor organoids and CAR-T cell co-culture models
| Â | Cancer cell lines | Tumor organoids | PDTXs |
|---|---|---|---|
Richness of variety | Various | Medium | Low |
Heterogeneity | + | +++ | ++ |
Difficultly of culture | Easy | Medium | Difficult |
Resource consumption | Low | Low | High |
High-throughput drugs screening | ++ | +++ | − |
Similarity with primary tumors | + | +++ | ++ |
Success rate of construction | + | +++ | ++ |
Gene Editing | ++ | ++ | + Editing on embryonic stem cells |
Presence of TME | − | ++ Can be preserved or reconstruction | ++ |