Fig. 3

PPP2R1B induced dephosphorylation of p-ERK and metastasis related markers. A The GSVA results showed that PPP2R1B is negatively associated with MEK signaling pathways. B p-ERK co-immunoprecipitated with PPP2R1B in SW480 CRC cells with or without Oxaliplatin. C protein expression involving PPP2R1B, ZEB1, E-cadherin, p-ERK, ERK, Snail in PPP2R1B siRNA group and negative control group in SW480. D The protein expression involving PPP2R1B, ZEB1, E-cadherin, p-ERK, ERK, Snail in PPP2R1B overexpression plasmid group and negative control group in HCT116. Bars indicate Mean ± S.E. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with the control, n = 3