Skip to main content
Fig. 5 | Cancer Cell International

Fig. 5

From: PPP2R1B abolishes colorectal cancer liver metastasis and sensitizes Oxaliplatin by inhibiting MAPK/ERK signaling pathway

Fig. 5

PPP2R1B regulate CRC cells Oxaliplatin chemosensitivity. A PPP2R1B mRNA level is associated with Oxaliplatin IC50 predicted by R package oncoPredict. B Protein of PPP2R1B, ZEB1, E-cadherin, Snail, p-ERK and ERK change in SW480 in PPP2R1B siRNA group and negative control group with or without Oxaliplatin treatment. C, D Quantitative analysis of the Western Blot was performed for SW480 cells using ImageJ software. E Chemosensitivity of SW480 treated with Oxaliplatin, in in PPP2R1B siRNA group and negative control group. F Chemosensitivity of SW480 treated with Oxaliplatin, in negative control group, PPP2R1B siRNA group and PPP2R1B siRNA plus PD98059 group. Bars indicate Mean ± S.E. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with the control, n = 3

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us