Fig. 1

Co-expression network constructed by WGCNA. a, b. A soft-thresholding power (β) of 4 was chosen for subsequent analysis based on the scale-free topology criterion in TCGA-CRC (a) and GSE17536 (b). c, d. Genes with similar expression patterns were clustered into co-expression modules in TCGA-CRC (c) and GSE17536 (d) based on dendrograms created from hierarchical clustering. e, f. Correlation between gene modules’ eigengenes and phenotypes in TCGA-CRC (e) and GSE17536 (f) datasets. g, h. Scatter plots of the module membership (MM) and gene significance (GS) of each gene in the tan module of TCGA-CRC (g) and the turquoise module of GSE17536 (h)