Fig. 4
From: ACADL-YAP axis activity in non-small cell lung cancer carcinogenicity
ACADL reduced the YAP activity in NSCLC. a The levels of YAP (Ser127) phosphorylation was elevated after ACADL overexpression were detected via western blot results. b Representative fluorescence images demonstrated the decrease of YAP nuclear aggregation level after ACADL overexpression (Scale bar: 25 μm). c The western blot results revealed the YAP protein level in nucleus was decreased after ACADL overexpression. d The qRT-PCR results suggested CTGF, CYR61, and ANKRD1 mRNA in NSCLCs cells were down-regulated after ACADL overexpression. ***P < 0.001. ACADL: Acyl-CoA dehydrogenase long chain. YAP: Yes-associated protein. NSCLC: Non-small cell lung cancer. CTGF: Connective tissue growth factor, CYR61: Cysteine rich angiogenic inducer 61, ANKRD1: Ankyrin repeat domain 1