Fig. 5
From: ACADL-YAP axis activity in non-small cell lung cancer carcinogenicity
XMU-MP-1 application partly abolished ACADL suppressed function on YAP in NSCLC cells. a The western blot results revealed XMU-MP-1 application in ACADL overexpression cell could partly rescue the level of YAP phosphorylation. b Representative fluorescence images demonstrated XMU-MP-1 application in ACADL overexpression cell could increase the YAP nuclear aggregation level (Scale bar: 25 μm). c The western blot results revealed XMU-MP-1 application in ACADL overexpression cell could rescue the level of YAP in nucleus. d The qRT-PCR results suggested XMU-MP-1 application in ACADL overexpression cell could rescue the mRNA expressions of CTGF, CYR61, and ANKRD1. * vs. Control with DMSO group; * P < 0.05; ** P < 0.01; *** P < 0.001. # vs. ACADL with DMSO group; ###P < 0.001. ACADL: Acyl-CoA dehydrogenase long chain. YAP: Yes-associated protein. NSCLC: Non-small cell lung cancer. CTGF: Connective tissue growth factor, CYR61: Cysteine rich angiogenic inducer 61, ANKRD1: Ankyrin repeat domain 1