Fig. 8
From: ACADL-YAP axis activity in non-small cell lung cancer carcinogenicity
ACADL inhibited growth of NSCLC cells in vivo by inhibiting the activation of YAP. a, b ACADL could promote the growth of NSCLC cells in vivo, while XMU-MP-1 application could partially inhibit the growth promoting effect of ACADL on NSCLC cells. c The expression of Ki67 and PCNA was significantly decreased in ACADL overexpression tumors. XMU-MP-1 application could partly rescue the phenomena. E-Cadherin expression was higher in ACADL group and was weaken after XMU-MP-1 application. * vs. Control group; **P < 0.01; ***P < 0.001. # vs. ACADL group; #P < 0.05; ##P < 0.01. ACADL: Acyl-CoA dehydrogenase long chain. YAP: Yes-associated protein. NSCLC: Non-small cell lung cancer