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Fig. 5 | Cancer Cell International

Fig. 5

From: Transmembrane protein 176B regulates amino acid metabolism through the PI3K-Akt-mTOR signaling pathway and promotes gastric cancer progression

Fig. 5

TMEM176B drives GC progression via the PI3K-Akt-mTOR signaling pathway. A Differentially expressed genes (DEGs) were subjected to KEGG pathway enrichment analysis. B Gene set enrichment analysis (GSEA) of DEGs. C, D WB determined the expression levels of ASNS proteins related to the PI3K-Akt-mTOR signaling pathway in GC cell lines after TMEM176B knockdown or overexpression. E HGC27 cell line with TMEM176B knockdown was treated with cycloheximide (CHX) to detect ASNS expression at various time points. F HGC27 cell line with TMEM176B knockdown was treated with dimethyl sulfoxide (DMSO), rapamycin, 3-methyladenine (3-MA), and MG132 to detect ASNS expression

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Cancer Cell International

ISSN: 1475-2867

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