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Fig. 6 | Cancer Cell International

Fig. 6

From: Transmembrane protein 176B regulates amino acid metabolism through the PI3K-Akt-mTOR signaling pathway and promotes gastric cancer progression

Fig. 6

mTOR inhibitors partially reverse the malignant GC-promoting effect of TMEM176B overexpression. A The efficiency of mTOR inhibition by rapamycin was measured in AGS cell lines overexpressing TMEM176B. B, C Impact of rapamycin on the clonogenic potential of AGS cell lines overexpressing TMEM176B. D, E Impact of rapamycin on the proliferation of AGS cell lines overexpressing TMEM176B was assessed by EdU assay. F, G Impact of rapamycin on migration and invasion of AGS cell lines overexpressing TMEM176B was assessed by Transwell assay. H, I Impact of rapamycin on apoptosis in AGS cell lines overexpressing TMEM176B. NC normal control, OE overexpression, DMSO dimethyl sulfoxide, RAPA rapamycin;*p < 0.05, **p < 0.01, ***p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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