Cancer Cell International

Table 2 Univariate and multivariate analysis of clinicopathological variables and TMEM176B expression associated with overall survival

From: Transmembrane protein 176B regulates amino acid metabolism through the PI3K-Akt-mTOR signaling pathway and promotes gastric cancer progression

Parameters	Univariate analysis		Multivariate analysis
Parameters	HR (95% CI)	P-value	HR (95% CI)	P-value
Gender (male vs female)	0.910(0.511–1.622)	0.750
Age (years) (< 61 vs ≥ 61)	1.272 (0.732–2.212)	0.393
Tumor location (upper vs middle + lower)	1.153 (0.643–2.068)	0.634
Tumor size (cm) (< 6 vs ≥ 6)	0.824 (0.482–1.408)	0.479
Depth of invasion (T1 + T2 vs T3 + T4)	1.578 (0.827–3.008)	0.166
Lymph node metastasis (absent vs present)	3.713 (1.474–9.353)	0.005^a	3.345 (1.103–10.145)	0.033^a
Differentiation (well + moderate vs poor)	1.648 (0.918–2.957)	0.094
TNM stage (I + II vs III + IV)	1.967 (1.034–3.739)	0.039^a	0.844 (0.386–1.843)	0.670
TMEM176B expression (low vs high)	2.515 (1.452–4.357)	0.001^a	2.124 (1.204–3.750)	0.009^a

^aStatistically significant (P < 0.05)

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