From: Roles and mechanisms of aberrant alternative splicing in melanoma — implications for targeted therapy and immunotherapy resistance
Targeted Gene
Effect
SRSF1
circMYC
Affect lactate dehydrogenase activity
SRSF2
/
T cell maturation
SRSF3
MDM4v6
p53-MDM4 axis
SRSF6
BIM
Inhibit apoptosis pathway
SRPK1
VEGF
Immunological susceptibility
SRPK2