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Table 1 SR family

From: Roles and mechanisms of aberrant alternative splicing in melanoma — implications for targeted therapy and immunotherapy resistance

 

Targeted Gene

Effect

SRSF1

circMYC

Affect lactate dehydrogenase activity

SRSF2

/

T cell maturation

SRSF3

MDM4v6

p53-MDM4 axis

SRSF6

BIM

Inhibit apoptosis pathway

SRPK1

VEGF

Immunological susceptibility

SRPK2

/

Immunological susceptibility