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Table 2 hnRNPs

From: Roles and mechanisms of aberrant alternative splicing in melanoma — implications for targeted therapy and immunotherapy resistance

 

Targeted Gene

Effect

hnRNP I (PTBP1)

CD44v6

T-cell homeostasis

hnRNP A1

Stress-induced antigens

Enhance translation and recognition by T lymphocytes

hnRNP A2B1

\

Apoptosis of melanoma stem cells

hnRNP C

p53

Cis-element in the 5′ coding region of p53 mRNA

hnRNP U

AKT

Cooperates with nuclear actin in transcriptional regulation