Fig. 1

IC–FCγR interactions lead to DC antigen presentation and T-cell activation. a When exposed to foreign antigens, PRRS and FcγRs can mediate the induction of dendritic cell maturation. During maturation, imDCs lose their endocytic capacity while increasing their capacity for antigen processing and presentation, driving their homing to lymph nodes, where they present antigens to naive CD4+ or CD8+ T cells. b ICs bind to FcγRs on the surface of DCs, are internalized and processed, and subsequently bind to neonatal FcRn, trafficking and MHC-mediated antigen presentation. c Matching of TCR with MHC molecules on DCs. d The activation of a T-cell depends on its interaction with APCs and requires three signals