Fig. 2

AlloIgG combined with TNFα and CD40L induced complete elimination of tumor cells. a Syngeneic BMDCs loaded with AlloIgG-IC activate T cells and prevent tumor recurrence in mice. b When AlloIgG was injected into tumors in autologous mice, TADC cannot transmit signals through their Fcγ receptor after contact with AlloIgG-IC in a highly immunosuppressed tumor microenvironment. c Combining tumor-binding AlloIgG with TNFα and CD40L enables TADC to internalize tumor antigens via the Fcγ receptor. These antigens are then processed by DCs and presented to T cells, which attack primary tumors and distant metastases