Fig. 3
From: Perspective view of allogeneic IgG tumor immunotherapy
Mechanisms of DC-mediated signaling by alloIgG action. a Stimulation of BMDCs with AlloIgG-IC resulted in a significant increase in phosphorylated MAPK p38, ERK1/2, and JNK, as well as robust phosphorylation of Akt. b Once monocytes are released from their bone marrow niche into the circulation, they markedly elevate the levels of phosphorylated SHP-1 and phosphatases that regulate Akt activation. c Simultaneous blockade of SHP-1 and Akt-regulating phosphatases (such as PTEN and SHIP-1) enables activation of TADCs and MoDCs. Green arrows represent our proposed potential TADC/MoDC activation signaling pathways by TNFα and CD40L