Table 4 Aptamer-drug conjugations as cancer-targeted therapeutics
Aptamer names | Aptamer | Target | Drug | Type of cancer | Refs. |
|---|---|---|---|---|---|
sgc8c | DNA | CCRF-CEM cell | Doxorubicin | T-cell acute lymphoblastic leukemia, T-cell ALL | [72] |
TLS11a-GC | DNA | LH86 cell | Doxorubicin | Human hepatocellular carcinoma | [73] |
MA3 | DNA | MUC1 protein | Doxorubicin | Human breast, liver &lung cancer | [74] |
HB5 | DNA | HER2 protein | Doxorubicin | Breast cancer | [75] |
EpDT3 & Scr-EpDT3 | RNA | EpCAM protein | Doxorubicin | Retinoblastoma | [76] |
E07 & mE07 | RNA | EGFR protein | Gemcitabine 5-fluorouracil | Pancreatic cancer | |
EpCAM aptamer | RNA | EpCAM protein | Doxorubicin | Colorectal cancer | [79] |
TLS11a-GC | DNA | HepG2Â cell | Doxorubicin | Hepatocellular carcinoma | [80] |
AP-1-M | DNA | CD133 protein | Doxorubicin | Anaplastic thyroid cancer | [81] |
AS1411/NucA | DNA | Nucleolin | Doxorubicin/Camptothecin | Breast cancer | [82] |
XQ-P3 | DNA | PD-L1 protein | Paclitaxel | Treating Triple-Negative Breast Cancer | [83] |
AS1411 | DNA | Nucleolin | Paclitaxel | Ovarian cancer | [84] |
CD117-specific aptamer #1F | DNA | CD117 | Methotrexate | Acute myeloid leukemia | [85] |
E3 | RNA | PC3 (PC-3) cells | Monomethyl auristatin E and F | Prostate cancer | [86] |
XQ-2d | DNA | CD71 | Monomethyl auristatin E | Uveal melanoma | [87] |
P19 | RNA | PDAC cell lines | Monomethyl auristatin E and derivative of maytansine 1/ | Pancreatic Tumor Cell | [88] |
HER2 RNA aptamer | RNA | HER2 | Mertansine | Breast Cancer | [89] |
S30-T1 | DNA | CD33 | Doxorubicin | Acute myeloid leukemia | [90] |
SQ-2 | RNA | ALPPL-2 | 5-fluoro-2′-deoxyuridine | Pancreatic ductal adenocarcinoma | [91] |
APTA12 (Gemcitabine incorporated G-quadruplex aptamer) | DNA | Nucleolin | Doxorubicin/ Gemcitabine | Breast cancer | [92] |
APTA12 (Gemcitabine incorporated G-quadruplex aptamer) | DNA | Nucleolin | Gemcitabine | Pancreatic cancer | [93] |
G12msi aptamer | DNA | GPC3 protein | Gemcitabine | Hepatocellular carcinoma | [94] |
PDGC21-T | DNA | MDA-MB-231 | Gemcitabine | Triple-negative breast cancer | [95] |
Modified type of AS1411 | DNA | Nucleolin | Gemcitabine | Pancreatic cancer | [96] |
ThioAp52 | DNA | MAGE-A3 | Doxorubicin | Breast, oral, pancreatic, and skin cancer | [97] |