Table 6 Aptamer-drug conjugations with nanocarriers/nanoparticles as cancer-targeted therapeutics
Chemotherapy | |||||
|---|---|---|---|---|---|
Aptamer names | Type of aptamer | Drug | Nanocarriers/nanoparticles | Type of cancer | Refs. |
MUC1(5TR1) | DNA | 5-fluorouracil | Chitosan carbon quantum dot | Breast Cancer | [147] |
Epirubicin | Poly (lactic-co-glycolic acid) | Breast Cancer | [148] | ||
Epirubicin | Super paramagnetic iron oxide nanoparticles | Colon cancer | [149] | ||
Doxorubicin | PEGylated liposome | Colon carcinoma | [150] | ||
SN-38 | Chitosan nanoparticles | Colon cancer | [151] | ||
SN-38 | Camptothecin, conjugated to hyaluronic acid | Colon cancer | [152] | ||
5-fluorouracil | Hyaluronan/chitosan nanoparticles | Colorectal adenocarcinoma | [153] | ||
Paclitaxel | Chitosan-coated human serum albumin nanoparticles | Breast cancer | [154] | ||
5TR1 and NAS-24 | DNA | Epirubicin | Selenium nanoparticles | Breast and colon cancer | [155] |
MUC1 and ATP aptamer | DNA | Epirubicin | DNA diamond nanostructure | Colon carcinoma and breast cancer | [156] |
AS1411 | Methotrexate | Chitosan-gold nanocluster | Lung cancer | [157] | |
Doxorubicin | Fe3O4@UiO-66-NH2 | Breast cancer | [158] | ||
Doxorubicin | Polyamid-amin dendrimer grafted persistent luminescence | [159] | |||
5-fluorouracil | Carboxymethyl chitosan | Breast cancer | [160] | ||
Epigallocatechin gallate | Chitosan-silica nanoparticles | Ovarian cancer cell lines | [161] | ||
Erlotinib | Chitosan nanoparticles | Non-small cell lung cancer | [162] | ||
5-fluorouracil | Hyaluronic acid sodium salt and alginic acid sodium salt | Skin cancer | [163] | ||
Paclitaxel | Human serum albumin | Breast cancer | [164] | ||
Docetaxel | Albumin | Colon Cancer | [165] | ||
Doxorubicin | Albumin nanoparticles loaded on iron oxide and gold nanoparticles | Breast cancer | [166] | ||
Ferrocene, and purpurin | Bovine serum albumin | Breast cancer | [167] | ||
Doxorubicin | Bovine serum albumin | Breast cancer | [168] | ||
AS1411 and FOXM1 Apt | DNA | Doxorubicin | Chitosan (CS)-Gold nanoparticles (AuNPs) | Lung cancer | [169] |
HPA aptamers (S1.5) | DNA | Paclitaxel | PEGylated PLGA nanoparticles | Triple-negative breast cancer | [170] |
Anti-PSMA | RNA | Doxorubicin | Thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPIONs) | Prostate cancer | [171] |
Sgc8c-aptamer | DNA | Doxorubicin | N-heterocyclic carbene (NHC)–gold(I) complexe | Leukemia | [172] |
Anti-EpCAM aptamer | DNA | Doxorubicin | Mesoporous silica nanoparticles | Colon cancer | [173] |
Radiotherapy | |||||
|---|---|---|---|---|---|
Aptamer names | Type of aptamer | Drug | Nanocarriers/nanoparticles | Type of cancer | Refs. |
AS1411 | DNA | - | Gold nanoclusters using bovine serum albumin capping agent | Breast Cancer | [104] |
Verapamil | Bovine serum albumin (BSA) coated silver nanoparticles (AgNPs) | Glioma | [174] | ||
GMT8 | DNA | - | PEGylated Ag@Au core–shell nanoparticles (GSGNPs) | Malignant glioma | [175] |
Immunotherapy | |||||
|---|---|---|---|---|---|
Aptamer names | Type of aptamer | Drug/others ingredient | Nanocarriers/nanoparticles | Type of cancer | Refs. |
AS1411 | DNA | CRISPR/Cas9 plasmid | Hyaluronic acid | Non-small cell lung cancer | [176] |
α-PD1 (engineered monoclonal antibodies against PD1) | PEG on nanomicelles | Breast cancer and hepatocellular carcinoma | [177] | ||
Anti-CD16 and anti-MUC1 | DNA | – | Amphipathic nanoparticles | adenocarcinomas (lung cancer and breast cancer) | [178] |
PD-L1 aptamer | DNA | Fexofenadine (FEXO) | Albumin nanoparticles | Colon cancer | [179] |
PD-L1 aptamer and AS1411 | DNA | – | Prussian blue nanoparticles (PBs) coated with platelet membrane (PM) | Breast cancer | [180] |
sTN145 | RNA | PD-L1 siRNA | PLGA-based polymeric nanoparticles | Triple-negative breast cancer | [181] |
APDL1(PD-L1 aptamer) | DNA | – | Gold nanorods | Non-small cell lung cancer | [182] |
CTLA-4 aptamer | DNA | Fexofenadine (FEXO) | Albumin nanoparticle | Colon cancer and breast cancer | [183] |
IL-4Rα aptamer | RNA | CpG oligodeoxynucleotide (ODN) | Liposome | Colon carcinoma | [184] |
Endoglin aptamer (ENG-Apt) | DNA | Interferon-inducible protein-10 (IP-10) | Liposome -based nanocapsules | Melanoma tumor | [185] |